NFAT-133 is an aromatic polyketide produced by Streptomyces sp.. NFAT-133 induces glucose uptake in differentiated L6 myotubes without activating the peroxisome proliferator-activated receptor-γ with an EC50 of 6.3 ± 1.8 μM. NFAT-133 inhibits transcription mediated by nuclear factor of activated T cells (NFAT), leading to the suppression of interleukin-2 expression and T cell proliferation.
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- Absolute configuration of NFAT-133, an aromatic polyketide with immunosuppressive and antidiabetic activity from actinomycetes. Yang Y. et al. J. Antiobiot. 2016, 69, 69.