NFAT-133

NFAT-133

$215.00 - 0.50 mg

$755.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-N2947
Synonyms
NFAT 133
CAS #
165133-85-7
Molecular Formula
C17H24O3
Molecular Weight
276.38
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

NFAT-133 is an aromatic polyketide produced by Streptomyces sp.. NFAT-133 induces glucose uptake in differentiated L6 myotubes without activating the peroxisome proliferator-activated receptor-γ with an EC50 of 6.3 ± 1.8 μM. NFAT-133 inhibits transcription mediated by nuclear factor of activated T cells (NFAT), leading to the suppression of interleukin-2 expression and T cell proliferation.

References

  • Simple aromatics identified with a NFAT-lacZ transcription assay for the detection of immunosuppressants. Burres N.S. et al. J Antibiot 1995, 48, 380.
  • Fermentation, isolation, structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667. Kulkarni-Almeida A.A. et al. AMB Express 2011, 1, 42.  
  • Absolute configuration of NFAT-133, an aromatic polyketide with immunosuppressive and antidiabetic activity from actinomycetes. Yang Y. et al. J. Antiobiot. 2016, 69, 69.

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