NFAT-133
Application Notes
NFAT-133 is an aromatic polyketide produced by Streptomyces sp.. NFAT-133 induces glucose uptake in differentiated L6 myotubes without activating the peroxisome proliferator-activated receptor-γ with an EC50 of 6.3 ± 1.8 μM. NFAT-133 inhibits transcription mediated by nuclear factor of activated T cells (NFAT), leading to the suppression of interleukin-2 expression and T cell proliferation.
References
- Simple aromatics identified with a NFAT-lacZ transcription assay for the detection of immunosuppressants. Burres N.S. et al. J Antibiot 1995, 48, 380.
- Fermentation, isolation, structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667. Kulkarni-Almeida A.A. et al. AMB Express 2011, 1, 42.
- Absolute configuration of NFAT-133, an aromatic polyketide with immunosuppressive and antidiabetic activity from actinomycetes. Yang Y. et al. J. Antiobiot. 2016, 69, 69.