Neosolaniol

Neosolaniol

$180.00 - 0.10 mg

$630.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-N1931
Synonyms
NSC 197212, Neozolaniol, Solaniol, Solaniol
CAS #
36519-25-2
Molecular Formula
C19H26O8
Molecular Weight
382.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Application Notes

Neosolaniol (solaniol), a trichothecene mycotoxin produced by Fusarium sp., is a metabolite of T-2 toxin. Neosolaniol is cytotoxic to human renal proximal tubule epithelial cells (RPTEC) and normal human lung fibroblasts (NHLF) with IC50 0.7–3.0 M albeit less potent than T-2 toxin. The parent T-2 toxin strongly induces apoptosis, however hydrolysis of T-2 at the C-8 position to neosolaniol diminishes the latter’s ability to induce DNA fragmentation. Neosolaniol inhibits synthesis of the disease resistance protein AvrRpm1 in Arabidopsis thaliana.

References

  • Solaniol, a toxic metabolite of Fusarium solani. Ishii K. et al.1971. Appl Microbiol. 1971, 22, 718.
  • Oxidative stress‑mediated cytotoxicity and metabolism of T‑2 toxin and deoxynivalenol in animals and humans: an update. Wu Q-H. et al. Arch Toxicol. 2014, 88, 1309.
  • Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice. Islam Z. et al. Biosci Biotechnol Biochem. 1998, 62, 1492.

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