Neohydroxyaspergillic acid is small polar metabolite found in Aspergillus subgenus Circumdati first observed by Weiss and co-workers in 1958. Structurally, neohydroxyaspergillic acid is part of the aspergillic acid class, analogues of which are broadly distributed throughout the genus Aspergillus. Neohydroxyaspergillic acid exhibits antibacterial and antiviral activity and, more recently, was shown to have antiprotozoan activity.