Narcotine (noscapine) is a non-narcotic alkaloid isolated from the opium poppy Papaver somniferum originally used for its antitussive and hypotensive effects. Narcotine inhibits bradykinin receptor activation in guinea pig airways. Narcotine is an antitumor agent that acts via the binding of its bioactive metabolite, 7-aminonoscapine, to the colchicine binding site of tubulin. Narcotine induces apoptosis via the PTEN/PI3K/mTOR signaling pathway and complexes with lysozyme. Narcotine has neuroprotective and antifibrotic activity.
- LXXXIII.—Synthesis and resolution of gnoscopine (dl-narcotine). Perkin W.H. et al. J Chem Soc Trans. 1911, 99, 775.
- Interaction of noscapine with the bradykinin mediation of the cough response. Ebrahimi S.A. et al. Acta Physiologica Hungarica 2003, 90, 147.
- Structural basis of noscapine activation for tubulin binding. Oliva M.A. et al. J Med Chem. 2020, 63, 849.
- Noscapine alleviates cerebral damage in ischemia-reperfusion injury in rats. Kawadkar M. et al. Naunyn Schmiedebergs Arch Pharmacol. 2020, doi: 10.1007/s00210-020-02005.
- Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A. Kach J. et al. J Biol Chem. 2014, 289, 7505.