Monazomycin

Monazomycin

$315.00 - 1 mg

$1,105.00 - 5 mg

All prices in Australian dollars

Code
BIA-M1400
CAS #
11006-31-8
Molecular Formula
C72H133NO22
Molecular Weight
1364.8
Purity
>90% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Application Notes

Monazomycin is a macrocyclic polyol lactone isolated from several species of Streptoverticillium, first reported in 1963. Monazomycin is active against Gram positive bacteria with weak Gram negative activity. In solution, monazomycin exists as hydrophilic clusters which, when adsorbed onto a lipid bilayer, can induce channel formation. Monazomycin is an important bioprobe for understanding membrane channels.

References

  • Monazomycin, a new antibiotic produced by a Streptomyces. Akasaki K. et al., J. Antibiot. 1963, 16, 127.
  • Structure of monazomycin, a new ionophorous antibiotic. Nakayama H. et al., Tet. Letters 1981, 22, 5217.
  • Kinetics of channel formation in bilayer lipid membranes (BLMs) and tethered BLMs, monazomycin and melittin. Becucci L. & Guidelli R. Langmuir 2007, 23, 5601.

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