Monascin

Monascin

$255.00 - 0.50 mg

$895.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-M1973
Synonyms
Monascoflavin, Monascoflavine
CAS #
21516-68-7
Molecular Formula
C21H26O5
Molecular Weight
358.43
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Monascin (monascoflavin) is a yellow-orange pigment isolated from the fungus, Monascus purpureus used to produce red yeast rice. The structure of monascin was elucidated in 1960. Monascin has a broad bioprofile, including anti-inflammatory, antioxidant, antidiabetic, immunomodulatory, neuroprotective and antitumor effects. Monascin is a PPAR-​γ agonist and attenuates proinflammatory mediators, including inducible nitric oxide synthase (iNOS) and cyclooxygenase-​2 (COX-​2) expression as well as nitric oxide (NO) and prostaglandin E(2) (PGE2) formation caused by ovalbumin-​induced inflammation in the human THP-​1 monocyte cell line. Monascin inhibits the skin tumor-initiating effects of peroxynitrite or UVB and the tumor-promoting effects of 12-​O-​tetradecanoylphorbol-​13-​acetate in a mouse model.

References

  • Monascoflavin. Ohashi M. et al. Bull Chem Soc Jpn. 1960, 33, 1630.
  • Monascus-​fermented metabolite monascin suppresses inflammation via PPAR-​γ regulation and JNK inactivation in THP-​1 monocytes. Hsu W-H. et al. Food Chem Toxicol. 2012, 50, 1178.
  • Anti-​tumor-​initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-​mold rice). Akihasa T. et al. Chem Biodiversity 2005, 2, 1305.

Other Products

Related products