Methoxyellipticine, 9-

Methoxyellipticine, 9-

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-M1952
Synonyms
9-Methoxyellipticin, NSC 69187
CAS #
10371-86-5
Molecular Formula
C18H16N2O
Molecular Weight
276.33
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

9-Methoxyellipticine is an alkaloid constituent of Bleekeria sp.. 9-Methoxyellipticine is a potent antitumor agent with IC50 values of 0.39, 1.9 and 0.39 μmol when tested against a range of human cell lines, including MCF7, its multidrug-resistant counterpart VCREMS,MDA-MB-231 and thTERT-HME1, respectively. 9-Methoxyellipticine inhibits the growth of and DNA, RNA and protein synthesis by L1210 leukemia cells via intercalation. 9-Methoxyellipticine is also a potent a potent antioxidant in DPPH and FRAP assays and induces haemolysis in human red blood cells. Extracts containing 9-methoxyellipticine inhibit Cdc25s phosphatases and are active in the carrageenan-induced rat paw edema assay. 9-Methoxyellipticine is also active against plasmodia and trypanosomes.

References

  • Alkaloids of Ochrosia elliptica Labill. Goodwin S.  et al. J Am Chem Soc. 1959, 81, 1903. 
  • Chemical and biological investigation of Ochrosia elliptica in Egypt. El-Sheikh R.A. et al. Rec Nat Prod. 2017, 1, 552.
  • Biochemical effects of ellipticine on leukemia L1210 cells. Li L.H. et al. Biochim Biophys Acta, Nucleic Acids Protein Synth. 1974, 353, 375. 
  • Antiplasmodial activity of synthetic ellipticine derivatives and an isolated analog. Montoia A. et al. Bioorg Med Chem Lett. 2014, 24, 2631.

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