Mer-NF5003E
Application Notes
Mer-NF5003E is a sesquiterpenoid mycotoxin isolated from Stachybotrys strains, first published in 1994 as an avian myeloblastosis virus (AMV) protease inhibitor. Mer-NF5003E is inactive against HIV due to host cell toxicity. An analogue, Mer-NF5003B has been isolated from fungal biomass and dust samples collected in a domestic facility and may be a useful biomarker to assess exposure to potentially harmful S. chartarum contamination.
References
- Mer-NF5003B, E and F, novel sesquiterpenoids as avian myeloblastosis virus protease inhibitors produced by Stachybotrys sp.. Kaneta R. et al., J. Antibiot. 1994, 47,727.
- Stachybotrys mycotoxins: from culture extracts to dust samples. Dosen I. et al., Anal. Bioanal. Chem. 2016, 408, 5513.