Meclocycline

Meclocycline

$180.00 - 5 mg

$630.00 - 25 mg

All prices in Australian dollars

Code
BIA-M1464
Synonyms
7-Chloro-6-methylene-oxytetracycline, GS 2989, NCS 78502
CAS #
2013-58-3
Molecular Formula
C22H21ClN2O8
Molecular Weight
476.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Application Notes

Meclocycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of chlortetracycline to yield an exocyclic 6-methylene. Meclocycline is a close structural analogue of methacycline. Like all tetracyclines, meclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. Meclocycline has been extensively cited in the literature with over 400 references.

References

  • 6-Methylenetetracyclines. I A new class of tetracycline antibiotics. Blackwood R.K. et al., J. Am. Chem. Soc. 1961, 83, 2773.
  • 6-Methylenetetracyclines. III.1 Preparation and Properties. Blackwood R.K. et al., J. Am. Chem. Soc. 1963, 85, 3943.

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