Manumycin A was isolated by Zeeck and colleagues at the University of Gottingen, Germany published in 1987. Manumycin A is a potent and selective inhibitor of Ras farnesyl transferase. Manumycin A induces apoptosis and inhibits angiogenesis, and has antibacterial, anti-inflammatory and antiparasitic activity. Manumycin A retards the development of atherosclerosis with concomitant alleviation of oxidative stress in apoE-deficient mice.