LL 15G256α
Application Notes
LL 15G256α is a macrocyclic polyester isolated from Hypoxylon oceanicum LL-15G256 using a bioassay guided approach. LL 15G256α is active in the os-1 assay, inhibiting biosynthesis of the fungal cell wall. LL 15G256α was patented by American Cyanamid in 1998 but did not reach the market.
References
- Cell wall-active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation. Abbanat D. et al. J Antibiot. 1998, 51, 296.
- Isolation and identification of antifungal polyesters from the marine fungus Hypoxylon oceanicum LL-15G256. Schlingmann G. et al. Tetrahed. 2002, 58, 6825.
- A modified screen for the detection of cell wall acting antifungal compounds. Kirsch D. & Lai M. J Antibiot. 1986, 39, 1620.