Linearmycin A

Linearmycin A

Linearmycin A

$245.00 - 0.5 mg

$860.00 - 2.5 mg

All prices in Australian dollars

Code
BIA-L2363
Synonyms
-
CAS #
163596-98-3
Molecular Formula
C64H101NO16
Molecular Weight
1140.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Linearmycin A is novel linear polyene antibiotic isolated from mycelial extracts of Streptomyces sp. Linearmycin A and B have similar, long linear structures terminating with amino and carboxylic acid groups. The carboxylic acid terminal of linearmycin A links to a tetraenone, whereas linearmycin B links to a pentaenone. Linearmycin A has antifungal activity against Candida albicans. Linearmycin A has antibacterial activity, causing cellular lysis and colony degradation of the Gram-positive bacterium Bacillus subtilis acting directly on the cytoplasmic membrane.

References

  • Sakuda S. et al. (1995). Linearmycin A, a novel linear polyene antibiotic. Tetrahedron Lett., 36, 2777.
  • Sakuda S. et al. (1996). Novel linear polyene antibiotics: linearmycins. J. Chem. Soc., Perkin Trans. 1, 2315.
  • Stubbendieck R.M. et al. (2018). Linearmycins are lytic membrane-targeting antibiotics. J. Antibiot. 71, 372.

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