Leporin A is a pyridone metabolite selectively accumulated in the sclerotia of Aspergillus leporis and reported by Gloer and co-workers, University of Iowa in 1991 as an antiinsectan. The N-methoxy-2-pyridone moiety of leporin A is to date unique among fungal natural products. Leporin A demonstrates insecticidal activity against the corn earworm Helicoverpa zea and mild antibacterial activity against B. subtilis. Leporin A is produced by a PKS-NRPS biosynthetic gene cluster, containing a rare multifunctional SAM-dependent enzyme that catalyses three pericyclic reactions leading to its dihydropyran core.