Kumbicin C is a bis-indolyl benzenoid isolated from a novel Aspergillus species, A. kumbius, by Piggott and co-workers in 2016. Structurally, kumbicin C is related to the petromicins found in a closely related species, A. muricatus and the asterriquinones from A. terreus. Biosynthetically, the unusual 2H-chromene ring system of kumbicin C is formed by cyclisation of the prenyl group of kumbicin D. Kumbicin C is active against tumor cell lines and bacteria at microgram potency.
- Kumbicins A–D: bis-indolyl benzenoids and benzoquinones from an Australian soil fungus, Aspergillus kumbius. Lacey H.J. et al., Aust. J. Chem. 2016, 69, 152.