Kotanin A is a biscoumarin first isolated from Aspergillus glaucus by Buchi and co-workers at Massechussets Institute of Technology when identifying the toxic principles from mould-infested rice in Thailand in 1971. Kotanin A analogues were found to be non-toxic to mammals and the toxic principles were later identified as aflatoxins. Kotanin A is a symmetric biscoumarin with S axis chirality. Kotanin A, with its characteristic UV spectrum, is a useful chemotaxonomic marker for the Aspergillus genus.
- Structure and synthesis of kotanin and desmethylkotanin. Metabolites of Aspergillus glaucus. Buchi G. et al., J. Org. Chem. 1971, 36, 1143.
- Orlandin: a nontoxic fungal metabolite with plant growth inhibiting properties. Culter H.G. et al., J. Agric. Food Chem. 1979, 27, 592.