Kigamicin C

Kigamicin C

$325.00 - 0.50 mg

$1,140.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-K1116
CAS #
680571-51-1
Molecular Formula
C41H47NO16
Molecular Weight
809.8
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. The mechanism of action is proposed to be via blockade of aPKB/Akt activation, caused by the withdrawal of nutrients. It is active in vivo against a human pancreatic cancer xenograft model. Kigamicin C also inhibits the growth of Gram positive bacteria including MRSA, but is not active against Gram negative bacteria.

References

  • Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation. Lu J. et al., Cancer Sci. 2004, 95, 547.
  • Kigamicins, novel antitumor antibiotics. II. Structure determination. Kunimoto S. et al., J. Antibiot. 2003, 56, 1012.
  • Kigamicins, novel antitumor antibiotics. I. Taxonomy, isolation, physico-chemical properties and biological activities. Kunimoto S. et al., J. Antibiot. 2003, 56, 1004.

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