JBIR-15 is a non-proteogenic cyclic tripeptide isolated from a marine sponge-derived Aspergillus sclerotiorum by researchers at BIRC, Japan in 2009. JBIR-15 is N-demethylaspochracin, the macrocycle comprising alanine, N-methylvaline and an ornithine cyclised through the delta rather than the alpha-amino group. The alpha amino is acylated with an octa-2,4,6-trienoic acid. JBIR-15 is known to be non-toxic to mammalian cell lines and insects but its biological activity is largely unexplored.
- Structure of aspochracin, an insecticidal metabolite of Aspergillus ochraceus. Myokei R. et al., Tet. Lett. 1969, 695.
- JBIR-15, a new aspochracin derivative, isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. Motohashi K. et al., Biosci. Biotechnol. Biochem. 2009, 73, 1898.