Isocyclosporin A

Isocyclosporin A

$160.00 - 1 mg

$560.00 - 5 mg

All prices in Australian dollars

Code
BIA-I1262
CAS #
59865-16-6
Molecular Formula
C62H111N11O12
Molecular Weight
1202.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Isocyclosporin A is a rearranged degradation product formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions. This rearrangement has been used as the basis of a HPLC fluorescence for quantifying cyclosporin A. The pharmacology of isocyclosporin A has received little attention.

References

  • Cyclosporin A, a peptide metabolite from Trichoderma polysporum, with remarkable immunosuppressive activity. Ruegger A. et al., Helv. Chim. Acta 1976, 59, 1075.
  • Hydrolysis of cyclosporin A: Identification of 1,11 seco-cyclosporin A and 4,5 seco-isocyclosporin A by FAB-MS/MS. Magni F. et al., Peptides 1995, 16, 1335.
  • Kinetics of acid-catalyzed degradation of cyclosporin A and its analogs in aqueous solution. Oliyai R. et al., Int. J. Pept. Protein Res. 1994, 43, 239.
  • Synthesis of a fluorescent derivative of cyclosporin A for high-performance liquid chromatography analysis. Fois R. A. & Ashley J. J. J. Pharm. Sci. 1991, 80, 363.

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