Indole-3-propionic acid

Indole-3-propionic acid

$230.00 - 25 mg

$65.00 - 5 mg

All prices in Australian dollars

IPA, IPA (auxin), NSC 3252, NSC 47831
Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

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Application Notes

Indole-3-propionic acid is a tryptophan metabolite long recognised as a plant growth regulator. Indole-3-propionic acid is produced by microbiota in the human gut, including Clostridium sporogenes. Indole-3-propionic acid is a potent antioxidant and free radical scavenger that binds to the pregnane X receptor in intestinal cells, thereby facilitating mucosal homeostasis and protecting against intestinal epithelial barrier damage. Indole-3-propionic acid is neuroprotective in vivo, inhibiting β-amyloid fibril formation. Indole-3-propionic acid inhibits the growth of E. coli in vitro via its ability to block endogenous tryptophan formation.


  • Growth responses of various plants to 3-​indolepropionic acid. Granick S. & Dunham H.W. Papers of the Michigan Academy of Science, Arts and Letters 1937, 22, 69.
  • Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Reiter R.J. et al. Ann NY Acad Sci. 1998, 854, 410.
  • Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats. Zhoa Z-H. et al. Exp Molec Med. 2019, 51, 1.

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