Indole-3-carboxaldehyde

Indole-3-carboxaldehyde

$230.00 - 25 mg

$65.00 - 5 mg

All prices in Australian dollars

Code
BIA-I2396
Synonyms
1H-Indole-3-methanal, 3-Formyl-1H-indole, 3-Formylindole, 3-Indolylformaldehyde
CAS #
487-89-8
Molecular Formula
C9H7NO
Molecular Weight
145.16
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

Indole-3-carboxaldehyde is an endogenous metabolite of plants and is produced in humans by the metabolism of L-tryptophan in Lactobacillus and other gastrointestinal bacteria. Indole-3-carboxaldehyde is an immunomodulator, acting as an agonist of the aryl hydrocarbon receptor in human intestinal immune cells, stimulating the production of interleukin-22. Indole-3-carboxaldehyde contributes to plant defences against phytopathogenic fungi and modulates the quorum sensing pathway in V. parahaemolyticus in vitro to reduce biofilm formation. Indole-3-carboxaldehyde can be used as a biomarker for cardiometabolic risk in humans.

References

  • Microbial metabolism of dietary components to bioactive metabolites: Opportunities for new therapeutic interventions. Zhang L.S. & Davies S.S. Genome Med. 2016, 8, 46.
  • Trichoderma-induced plant immunity likely involves both hormonal- and camalexindependent mechanisms in Arabidopsis thaliana and confers resistance against necrotrophic fungus Botrytis cinerea. Contreras-Cornejo H.A. et al. Plant Signal Behav. 2011, 6, 1554.
  • In vitro evaluation of indole-3-carboxaldehyde on Vibrio parahaemolyticus biofilms. Murugan R. et al. Biologia 2016, 71, 247—255.

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