Hygromycin B

Hygromycin B

$60.00 - 5 mg

$210.00 - 25 mg

All prices in Australian dollars

Code
BIA-H1562
Synonyms
Antihelmycin
CAS #
31282-04-9
Molecular Formula
C20H37N3O13
Molecular Weight
527.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Hygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2.

References

  • Hygromycin B, its production and treatment of intestinal parasites. McQuire J.M. and Mann R.L. US Patent 3,018,220 1962.
  • Hygromycin I. Preliminary studies on the production and biological activity of a new antibiotic. Pettinger R.C. et al., Antibiot. Chemother. 1953, 3, 1268.
  • Studies on the mode of action of hygromycin B, an inhibitor of translocation in eukaryotes. Gonzalez A. et al., Biochim. Biophys. Acta 1978, 521, 459.

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