Himgaline

Himgaline

$199.00 - 0.50 mg

$697.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-H1747
Synonyms
(-)-Himgaline
CAS #
16585-08-3
Molecular Formula
C20H31NO2
Molecular Weight
317.47
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Himgaline is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimima sp., a magnolia native to northern Australia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. There are no specific reports of himgaline’s biological activity, however the related himbacine and analogues inhibit muscarinic receptors with 10-fold selectivity for M2 over M1 receptors.

References

  • The chemical constituents of Galbulimima species. V. The isolation of further alkaloids. Binns S.V. et al., Aust. J. Chem. 1965, 18, 569.
  • The chemical constituents of Galbulimima species. X. The structure of himgaline. Mander L.N. et al., Aust. J. Chem. 1967, 20, 1705 – 1718.
  • Progress toward the syntheses of (+)-GB 13, (+)-himgaline, and himandridine. New insights into intramolecular imine/enamine aldol cyclizations. Evans D.A. et al., J. Am. Chem. Soc. 2012, 134, 8162.

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