Himbadine
Application Notes
Himbadine is a piperidine alkaloid with a polycyclic scaffold first isolated from Galbulimima sp. a magnolia species native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. The bioactivity of himbadine has not been extensively investigated but its close structural relationship to other Galbulimima alkaloids suggests a possible affinity for muscarinic receptors.
References
- The chemical constituents of Himantandra species. II. The isolation of the alkaloids of Himantandra baccata and Himantandra belgraveana. Brown R.F.C. et al., Aust. J. Chem. 1956, 9, 283.
- The chemical constituents of Galbulimima species IX. The structures of himbadine and alkaloid G.B. 13. Mander L.N. et al., Aust. J. Chem. 1967, 20, 1473.
- Structures of new alkaloids from rain forest trees Galbulimima belgraveana and Galbulimima baccata in Papua New Guinea, Indonesia, and Northern Australia. Lan P. et al., ACS Omega 2018, 3, 1912.