Hecogenin acetate
Hecogenin acetate
$65.00 - 1 mg
$230.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-H1764
- Synonyms
- 3β-Acetoxy-5α-spirostan-12-one, NSC 15489
- CAS #
- 915-35-5
- Molecular Formula
- C29H44O5
- Molecular Weight
- 472.67
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes
Hecogenin acetate is a steroidal saponin first published in 1943 by Marker and colleagues at Penn State University, USA and isolated from plants of the Agave genus. Hecogenin acetate induces cell cycle arrest and senescence, and modulates ERK1/2 phosphorylation and MMP-2 production. Hecogenin acetate has nociceptive activity mediated by opioid receptors and endogenous analgesic mechanisms.
References
- Sterols. CLVII. Sapogenins. 69. Isolation and structures of thirteen new steroidal sapogenins. New sources for known sapogenins. Marker R.E. et al., J. Am.Chem. Soc. 1943, 65, 1199.
- Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line. Gasparotto J. et al., Anticancer Agents Med. Chem. 2014, 14, 1128.
- Evidence for the involvement of descending pain-inhibitory mechanisms in the Antinociception effect of hecogenin acetate. Gama K.B. et al., J. Nat. Prod. 2013, 76, 4, 559.
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