Hecogenin acetate

Hecogenin acetate

Hecogenin acetate

$70.00 - 1 mg

$245.00 - 5 mg

All prices in Australian dollars

Code
BIA-H1764
Synonyms
3β-Acetoxy-5α-spirostan-12-one, NSC 15489
CAS #
915-35-5
Molecular Formula
C29H44O5
Molecular Weight
472.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol, DMSO.

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Product Data Sheet

Application Notes

Hecogenin acetate is a steroidal saponin first published in 1943 by Marker and colleagues at Penn State University, USA and isolated from plants of the Agave genus. Hecogenin acetate induces cell cycle arrest and senescence, and modulates ERK1/2 phosphorylation and MMP-2 production. Hecogenin acetate has nociceptive activity mediated by opioid receptors and endogenous analgesic mechanisms.

References

  • Sterols. CLVII. Sapogenins. 69. Isolation and structures of thirteen new steroidal sapogenins. New sources for known sapogenins. Marker R.E. et al., J. Am.Chem. Soc. 1943, 65, 1199.
  • Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line. Gasparotto J. et al., Anticancer Agents Med. Chem. 2014, 14, 1128.
  • Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. Gama K.B. et al., J. Nat. Prod. 2013, 76, 4, 559.

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