Hancockiamide B is a member of an unusual family of N-cinnamoylated piperazines from the Australian soil fungus Aspergillus hancockii. Hancockiamide B has moderate activity against murine myeloma NS-1 cells. The producing organism, A. hancockii, has the capacity to degrade cellulose, hemicellulose, lignin, pectin, starch, chitin, cutin and fructan as nutrient sources.