Haenamindole
Application Notes
Haenamindole was first isolated from an undescribed marine-derived Pencillium species by Ahn and colleagues, Korea Research Institute of Bioscience and Biotechnology in 2015. Haenamindole is the N-hydroxy derivative of citreoindole, an unusual diketopiperazine metabolite with antitumor activity. Haenamindole exhibits antiinsectan activity against the fall armyworm Spodoptera frugiperda, but is reported as having no antimicrobial and or antitumor activity.
References
- Kim J.W. et al. (2015). Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005. BMCL, 25, 5398.
- Matsunaga K. et al. (1991). Isolation and structure of citreoindole, a new metabolite of hybrid strain KO 0052 derived from Penicillium citreoviride B. IFO 6200 and 4692. Tetrahedron Lett., 32, 6883.
- Hwang I.H. et al. (2016). Haenamindole and fumiquinazoline analogs from a fungicolous isolate of Penicillium lanosum. J. Antibiot., 69, 631.
- Hamed A. et al. (2021). Meleagrin from marine fungus Emericella dentata Nq45: Crystal structure and diverse biological activity studies. Nat. Prod. Rep., 35, 3830.