$100.00 - 1 mg
$350.00 - 5 mg
All prices in Australian dollars
- Aspergillin, SN 12879, SN 12870
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Gliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species of Gliocladium, Aspergillus and Penicillium. At the cellular level gliotoxin inhibits a broad range of unrelated mechanisms, including inhibition of chymotrypsin-like activity of the 20S proteasome and Ca2+ release from mitochondria, activation of transcription factor NF-κB in response to a variety of stimuli in T and B cells, anti-inflammatory activity, and inhibition of farnesyltransferase and geranylgeranyltransferase. The mode of action appears to be via covalent interaction with proteins through mixed disulphide formation. Gliotoxin inhibits a number of thiol-requiring enzymes and also displays antioxidant and immunomodulatory activity.
- Gliotoxin, the antibiotic principle of Gliocladium fimbriatum. I. Production, physical and biological properties. Johnson D. et al., JACS 1943, 65, 2005.
- The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis. Gardiner D. M. et al., Microbiology 2005, 151, 1021.
- Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo. Vigushin D. M. et al., Med. Oncol. 2004, 21, 21.
- The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB. Pahl, H. L. et al., J.Exp. Med. 1996, 183, 1829.
- Gliotoxin stimulates Ca2+ release from intact rat liver mitochondria. Schweizer M. & Richter C. Biochemistry 1994, 33, 13401.