Fumagillin

Fumagillin

$180.00 - 1 mg

$630.00 - 5 mg

All prices in Australian dollars

Code
BIA-F1256
Synonyms
Fumadil B, H-3, NSC 9168, U 5762, TNP-470
CAS #
23110-15-8
Molecular Formula
C26H34O7
Molecular Weight
458.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Fumagillin is a polyene mycotoxin isolated from Aspergillus fumigatus in 1951 as a potent antiprotozoan for the treatment of amoebiasis. More recently, fumagillin has been shown to inhibit endothelial cell proliferation and angiogenesis by inhibiting methionine aminopeptidase-2 (MetAP-2).

References

  • Fumagillin (H-3), a new antibiotic with amebicidal properties. McCowen M. C. et al., Science 1951, 23, 202.
  • Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2. Griffith E. C. et al., PNAS 1998, 95, 15183.
  • Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Lefkove B. et al., Expert Rev. Anti Infect. Ther. 2007, 5, 573.

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