Frequentin is a polar neutral metabolite isolated from P. frequentans by Curtis and co-workers at ICI in 1951. Frequentin is a cyclitol-like metabolite bearing a heptadiene chain. Frequentin, the aldehyde analogue of palitantin, exists as the hydroxymethylene in solution. Frequentin has been found in a number of Penicillium species and is a useful metabolite for chemotaxonomy of the genus. Frequentin is a potent antifungal active with minimal toxicity to mammalian cells.
- Frequentin: an antibiotic produced by some strains of Penicillium frequentans Westling. Curtis P.J. et al., Nature 1951, 167, 557.
- A structural relationship between frequentin and palitantin. Curtis P.J. and Duncanson L.A., Biochem. J. 1952, 51, 276.