Erythromycin A oxime

Erythromycin A oxime

$110.00 - 5 mg

$385.00 - 25 mg

All prices in Australian dollars

Code
BIA-E1381
CAS #
111321-02-9
Molecular Formula
C37H68N2O13
Molecular Weight
749
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

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Application Notes

Erythromycin A 9-oxime is a semi-synthetic analogue of erythromycin prepared as means of overcoming acid lability and improving oral absorption of erythromycin A while retaining comparable antibacterial potency. Although not developed as a commercial product, erythromycin oxime was pivotal in the development of the ring expanded aza-erythromycins (e.g. azithromycin) and the oxime ethers (e.g. roxithromycin).

References

  • New ether oxime derivative of erythromycin A structure-activity relationship study. Gasc J-C. et al., J. Antibiot. 1994, 44, 313.
  • Erythromycin series. Part 11. Ring expansion of erythromycin A oxime by the Beckmann rearrangement. Djokic S. J. Chem. Soc. Perkin Trans. 1986, 1, 1881.

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