Erythromycin A oxime
Application Notes
Erythromycin A 9-oxime is a semi-synthetic analogue of erythromycin prepared as means of overcoming acid lability and improving oral absorption of erythromycin A while retaining comparable antibacterial potency. Although not developed as a commercial product, erythromycin oxime was pivotal in the development of the ring expanded aza-erythromycins (e.g. azithromycin) and the oxime ethers (e.g. roxithromycin).
References
- New ether oxime derivative of erythromycin A structure-activity relationship study. Gasc J-C. et al., J. Antibiot. 1994, 44, 313.
- Erythromycin series. Part 11. Ring expansion of erythromycin A oxime by the Beckmann rearrangement. Djokic S. J. Chem. Soc. Perkin Trans. 1986, 1, 1881.