Erythromycin A enol ether
Erythromycin A enol ether
$160.00 - 1 mg
$560.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-E1347
- CAS #
- 33396-29-1
- Molecular Formula
- C37H65NO12
- Molecular Weight
- 715.9
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes
Erythromycin A enol ether is a degradation product of erythromycin formed under acidic conditions by C6–OH internal attack on the C9 ketone to produce a cyclic enol ether. The rearrangement results in a loss of antibiotic activity. This single reaction was the prime driver for the development of second and third generation erythromycins. Erythromycin A enol ether is an important standard for stability studies.
References
- Decomposition kinetics of erythromycin A in acidic solutions. Cachet T. et al., Int. J. Pharm. 1989, 55, 59.
- A new mechanism for the decomposition of erythromycin A in acidic medium. Vinckier C. et al., Int. J. Pharm, 1989, 55, 67.