Eprinomectin B1b is a semi-synthetic analogue of avermectin B1b prepared by oxidation of the 4”-hydroxy moiety and reductive amination followed by acetylation. Eprinomectin B1b is the minor component (<10%) of the commercial product for endo- and exo-parasite control, eprinomectin. Members of the avermectin/milbemycin class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectins and milbemycins are also potent insecticides and acaricides.
- 4-Keto- and 4-amino-4-deoxy avermectin compounds and substituted amino derivatives thereof. Mrozik H.H. et al., 1984 US Patent 4,427,663.
- Synthesis of 4"-epi-amino-4"-deoxyavermectins B1. Cvetovich R.J. et al., J. Org. Chem. 1994, 59, 7704.
- Efficacy in sheep and pharmacokinetics in cattle that led to the selection of eprinomectin as a topical endectocide for cattle. Shoop W.L. et al., Int. J. Parasitol. 1996, 26, 1227.