Epanorin, ent-
Application Notes
ent-Epanorin is the D-isomer of the naturally occurring L-form of epanorin. Epanorin is a member of the pulvinic acid family, with a tetronic acid core bound to the amino acid, L-leucine. ent-Epanorin is synthesised by reacting D-leucine methyl ester with pulvinic acid lactone. ent-Epanorin is moderately to weakly active against Gram positive organisms, B. subtilis and S. aureus, being more potent than epanorin. ent-Epanorin is more active than epanorin against G. duodenalis, but less active against murine myeloma NS-1.
References
- King D.E. et al. (2006). New classification and update on the quinolone antibiotics. Am. Fam. Physician 61, 3741.
- Palacios-Moreno J. et al. (2019). Epanorin, a lichen secondary metabolite, inhibits proliferation of MCF-7 breast cancer cells. Biol Res., 52, 55.
- James P.J.C. et al. (2023). Synthesis, characterization, and bioactivity of the lichen pigments pulvinamide, rhizocarpic acid, and epanorin and congeners. J. Nat. Prod., 86, 550.



