Emodin

Emodin

$160.00 - 1 mg

$560.00 - 5 mg

All prices in Australian dollars

Code
BIA-E1706
Synonyms
1,3,8-Trihydroxy-6-methylanthraquinone; 1,6,8-Trihydroxy-3-methylanthraquinone; 3-Methyl-1,6,8-trihydroxyanthraquinone; 4,5,7-Trihydroxy-2-methylanthraquinone; Archin; Emodin; Emodol; Frangula emodin; Frangulic acid; NSC 408120; NSC 622947; Rheum emodin
CAS #
518-82-1
Molecular Formula
C15H10O5
Molecular Weight
270.24
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Emodin is an anthraquinone pigment widely distributed in fungi and plants with a long tradition of use in herbal medicines. Structurally, emodin is 1,3,8-trihydroxy-6-methylanthraquinone and, like many simple anthraquinones, demonstrates a broad biological profile with weak to moderate antimicrobial, insecticidal and antitumor activity. More recently, emodin has been identified as a potent inhibitor of Lck, 11β-hydroxysteroid dehydrogenase Type 1 and monoamine oxidase, among other pathways. Emodin has been extensively researched with over 6,000 citations in Scifinder. Emodin is an important standard for chemical and bioassay dereplication of microbial extracts.

References

  • Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase Type 1 and ameliorates metabolic disorder in diet-induced obese mice. Feng Y. et al., Brit. J. Pharmacol. 2010, 161, 113.
  • Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. Lu Y. et al., Biochem Pharmacol. 2011, 82, 1700.
  • Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer. Lin S. et al., Oncology Rep. 2011, 26, 81.

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