Δ2-Doramectin is an irreversible base degradation product of doramectin found in animals treated with doramectin and in the environment. Δ2-Doramectin is formed by rearrangement of the naturally occurring Δ3-group in doramectin to the 2-position. Despite the importance of doramectin as an anthelmintic in animal health, there are no published reports of the biological activity or the levels of Δ2-Doramectin in animals or in the environment.
- Base-catalyzed isomerization of avermectins. Pivnichny J.V. et al., J. Agric. Food Chem. 1988, 36, 826.
- Direct determination of avermectins in plasma at nanogram levels by High-Performance Liquid Chromatography. Pivnichny J.V. et al., J. Pharm. Sci. 1980, 72, 1447.