Dihydronovobiocin

Dihydronovobiocin

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-D1887
CAS #
29826-16-2
Molecular Formula
C31H38N2O11
Molecular Weight
614.64
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Dihydronovobiocin is a semi-synthetic member of the novobiocin aminocoumarin antibiotic family prepared by reduction of the prenyl double bond and published in 1956. Dihydronovobiocin is an inhibitor of the bacterial type II topoisomerase, DNA gyrase. Dihydronovobiocin is equipotent to novobiocin against S. aureus in vivo, including resistant strains, and is active against Mycobacterium tuberculosis. Dihydronovobiocin entered clinical development in the 1960s but did not progress to market.

References

  • Novobiocin and some derivatives. Rolland G. et al., Farmaco, Edizione Scientifica 1956, 11, 549.
  • Microbiological activity of novobiocin. Solotorovsky M. et al., Antibiot. Chemother. 1958, 8, 86.
  • The in vitro and in vivo antituberculous activity of dihydronovobiocin. Tacquet A. et al., J. Ann. de l'Institut Pasteur de Lille 1959, 10, 61.

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