$233.00 - 0.25 mg
$816.00 - 1 mg
All prices in Australian dollars
- Anguidine, Anguidin, DAS, NSC 141537, NSC 177378
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in methanol or DMSO
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Diacetoxyscirpenol is a type A trichothecene mycotoxin produced by various Fusarium sp. infecting grains. Diacetoxyscirpenol is a potent inhibitor of human Jurkat T-cell line, inducing apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1. Diacetoxyscirpenol inhibits hypoxia-inducible factor 1, which promotes the progression of malignancy by stimulating angiogenesis. Diacetoxyscirpenol induces anorexia in animal models, increasing the plasma levels of the gut satiety hormones peptide YY3-36 and glucose-dependent insulinotropic polypeptide.
- Fusarium toxins of the scirpentriol subgroup: a review. Schollengerger M. et al. Mycopath. 2007, 164, 101.
- Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Lee D.H. et al. Biol Pharm Bull. 2006, 29, 648.
- Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1 in human Jurkat T cells. Jun D.Y. et al. Tox Appl Pharmacol. 2007, 222, 190.
- Role of peptide YY3-36 and glucose-dependent insulinotropic polypeptide in anorexia Induction by Trichothecences T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol. Zhang J. et al. Toxicol Sci. 2017, 159, 203.