Diacetoxyscirpenol

Diacetoxyscirpenol

$255.00 - 0.25 mg

$895.00 - 1 mg

All prices in Australian dollars

Code
BIA-D1929
Synonyms
Anguidine, Anguidin, DAS, NSC 141537, NSC 177378
CAS #
2270-40-8
Molecular Formula
C19H26O7
Molecular Weight
366.41
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Diacetoxyscirpenol is a type A trichothecene mycotoxin produced by various Fusarium sp. infecting grains. Diacetoxyscirpenol is a potent inhibitor of human Jurkat T-cell line, inducing apoptosis by activation of caspase-​8 and interruption of cell cycle progression by down-​regulation of cdk4 and cyclin B1. Diacetoxyscirpenol inhibits hypoxia-inducible factor 1, which promotes the progression of malignancy by stimulating angiogenesis. Diacetoxyscirpenol induces anorexia in animal models, increasing the plasma levels of the gut satiety hormones peptide YY3-36 and glucose-dependent insulinotropic polypeptide.

References

  • Fusarium toxins of the scirpentriol subgroup: a review. Schollengerger M. et al. Mycopath. 2007, 164, 101.
  • Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Lee D.H. et al. Biol Pharm Bull. 2006, 29, 648.
  • Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-​8 and interruption of cell cycle progression by down-​regulation of cdk4 and cyclin B1 in human Jurkat T cells. Jun D.Y. et al. Tox Appl Pharmacol. 2007, 222, 190.
  • Role of peptide YY3-36 and glucose-dependent insulinotropic polypeptide in anorexia Induction by Trichothecences T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol. Zhang J. et al. Toxicol Sci. 2017, 159, 203.

Other Products

Related products