Descarbamylnovobiocin

Descarbamylnovobiocin

$225.00 - 1 mg

$790.00 - 5 mg

All prices in Australian dollars

Code
BIA-D1882
Synonyms
Descarbamoylnovobiocin, Decarbamylnovobiocin, Novclobiocin 103
CAS #
75057-97-5
Molecular Formula
C30H35NO10
Molecular Weight
569.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Descarbamylnovobiocin is a member of the novobiocin aminocoumarin antibiotic family found as a minor co-metabolite of novobiocin fermentation and produced as an alkaline degradation product. Like novobiocin, descarbamylnovobiocin is an inhibitor of the bacterial type II topoisomerase, DNA gyrase. It is less effective than novobiocin in eliminating the wild-type plasmid pMG110 from E. coli.

References

  • Decarbamoylnovobiocins. Wolf F.J. US Patent 2938899, 1960.
  • Elimination of plasmid pMG110 from Escherichia coli by novobiocin and other inhibitors of DNA gyrase. Hooper D.C. et al., Antimicrob. Agents Chemother. 1984, 25, 586.
  • Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis. Flatman R.H. et al., Antimicrob. Agents Chemother. 2006, 50, 1136.

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