Deoxyfunicone is a γ-pyrone metabolite produced by Penicillium sp.. Deoxyfunicone stimulates radicle growth of Chinese cabbage and lettuce seedlings at 10 – 50 µg/mL. Deoxyfunicone has potent antifungal activity and significantly potentiates the effect of micofungin against C. ablicans. Deoxyfunicone inhibits production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated BV2 microglial cells, with IC50 11μM. Deoxyfunicone inhibits the activity of PTP1B, with an IC50 value of 24μM, by binding to the active site of the enzyme. Deoxyfunicone is reported to have antiviral activity.
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