Deoxyfunicone

Deoxyfunicone

$240.00 - 0.50 mg

$840.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-D2869
CAS #
137461-36-0
Molecular Formula
C19H18O7
Molecular Weight
358.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Deoxyfunicone is a γ-pyrone metabolite produced by Penicillium sp.. Deoxyfunicone stimulates radicle growth of Chinese cabbage and lettuce seedlings at 10 – 50 µg/mL. Deoxyfunicone has potent antifungal activity and significantly potentiates the effect of micofungin against C. ablicans. Deoxyfunicone inhibits production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated BV2 microglial cells, with IC50 11μM. Deoxyfunicone inhibits the activity of PTP1B, with an IC50 value of 24μM, by binding to the active site of the enzyme. Deoxyfunicone is reported to have antiviral activity.

References

  • Deoxyfunicone, a new γ-pyrone metabolite from a resorcylide producing fungus (Penicillium). Sassa T. et al. Agric Biol Chem., 1991, 55, 2415.
  • Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromyces flavus FKI-0076. Arai M. et al. J Antibiot. 2002, 55, 172.
  • Anti-inflammatory and protein tyrosine phosphatase 1b inhibitory metabolites from the antarctic marine-derived fungal strain Penicillium glabrum SF-7123. Ha T.M. et al. Mar Drugs 2020, 18, 247.

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