Daunomycinone

Daunomycinone

$180.00 - 1 mg

$630.00 - 5 mg

All prices in Australian dollars

Code
BIA-D2310
Synonyms
(+)-Daunomycinone, Daunomycin aglicone, Daunomycinon, Daunorubicin aglycone, Daunorubicinone, Leukaemomycinone C, NSC 109351
CAS #
21794-55-8
Molecular Formula
C21H18O8
Molecular Weight
398.36
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

Daunomycinone (daunorubicinone) is the aglycone precursor of daunomycin, an anthracycline antitumor agent. Daunomycinone has been used as the scaffold for developing new anthracyclines. Daunomycinone is active against tumor cell lines, L1210 and P388 (ED50 8.9 and 21.6 µg/mL, respectively) but inactive against KB cell line.

References

  • Daunomycin. I. The structure of daunomycinone. Arcamone F. et al. J Am Chem So. 1964, 86, 5334.
  • Synthesis and antitumor activity of sugar-ring hydroxyl analogues of daunorubicin. Fuchs E.F. et al. J Med Chem. 1979, 22, 46.
  • Synthesis and biological activity of (7S)​-​O-​epoxyalkyl derivatives of daunomycinone. Prikrylova V. et al. J Antibiot. 1985, 38, 1714.

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