Cytosporone B

Cytosporone B

Cytosporone B

$160.00 - 0.25 mg

$560.00 - 1 mg

All prices in Australian dollars

Code
BIA-C3160
Synonyms
Dothiorelone G
CAS #
321661-62-5
Molecular Formula
C18H26O5
Molecular Weight
322.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol, DMSO.

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Product Data Sheet

Application Notes

Cytosporone B is a polyketide first isolated from two undescribed fungal strains belonging to the genera Cytospora and Diaporthe by Clardy and collaborators at Cornell University and Wyeth Research, USA in 2000. Cytosporone B has antitumor activity, specifically binding to the ligand-binding domain of the nuclear orphan receptor Nur77. Cytopsorone B is also active against influenza A virus and as a biological preservative to control citrus decay.

References

  • The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Brady S. et al. Org. Lett. 2000, 2, 4043.
  • Cytosporone B is an agonist for nuclear orphan receptor Nur77. Zhan Y. et al. Nature Chem. Biol. 2008, 4, 548.
  • Treatment with the NR4A1agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice. Egarnes B. et al. PLoS ONE 2017, 2(10):e0186639.

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