Cytochalasin D

Cytochalasin D

$138.00 - 1 mg

$483.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1170
Synonyms
Zygosporin A
CAS #
22144-77-0
Molecular Formula
C30H37NO6
Molecular Weight
507.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Cytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumor agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.

References

  • Antitumor activity of cytochalasin D: Katagiri K. and Matsuura S. J. Antibiot. 1971, 24, 722.
  • Effects of cytochalasin and phalloidin on actin: Cooper J. A. J. Cell. Biol. 1987, 105, 1473
  • Myosin-actin interaction plays an important role in human immunodeficiency virus type 1 release from host cells. H. Sasaki, H. et al., ; PNAS 1995, 92, 2026.

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