cyclo(L-Leu-L-Trp)

cyclo(L-Leu-L-Trp)

$200.00 - 5 mg

$700.00 - 25 mg

All prices in Australian dollars

Code
BIA-C1711
Synonyms
(3S,6S)-3-(1H-Indol-3-ylmethyl)-6-(2-methylpropyl)-2,5-piperazinedione; Cyclo(L-leucyl-L-tryptophyl) (8CI); BP II; Cyclo(Trp-Leu);
CAS #
15136-34-2
Molecular Formula
C17H21N3O2
Molecular Weight
299.37
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite first isolated from Penicillium aurantiovirens in 1989. Since then, cyclo(L-Leu-L-Trp) has been reported from other fungi and bacteria and is likely to be broadly distributed across microbes and plants. Cyclo(L-Leu-L-Trp) has a bitter taste and is used as a standard in flavor and taste research. Like other diketopiperazines, cyclo(L-Leu-L-Trp) appears in several recent patents covering a diverse range of diketopiperazines with broad therapeutic claims.

References

  • Biosynthesis of leucyl-tryptophanyl-diketopiperazine by a culture of Penicillium aurantiovirens and the characteristics of its production. Solov'eva T.F. et al., Mikrobiologiya 1989, 58, 393.
  • Rapid entry of bitter and sweet tastants into liposomes and taste cells: implications for signal transduction. Peri I. et al., Am. J. Physiol. 2000, 278, C17.
  • Brevicompanine C, cyclo-(D-Ile-L-Trp), and cyclo-(D-Leu-L-Trp), plant growth regulators from Penicillium brevi-compactum. Kimura Y. et al., J. Nat.Prod. 2005, 68, 237.

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