Cryptopleurine

Cryptopleurine

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1958
Synonyms
(R)-(-)-Cryptopleurine, NSC 19912, Cryptopleurine
CAS #
482-22-4
Molecular Formula
C24H27NO3
Molecular Weight
377.48
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

Cryptopleurine is a phenanthroquinolizidine secondary metabolite from Cryptocarya pleurosperma first reported by de la Lande, Melbourne University, Australia in 1948 and its structure revised in 1954. Cryptopleurine has antifungal activity via inhibition of the 40S ribosomal subunit blocking translocation. Cryptopleurine has antiviral and cytotoxic activity, targeting the NF-​κB pathway.

References

  • The alkaloids of Cryptocarya pleurosperma. De la Lande I.S. Aust J Exp Biol Med Sci. 1948, 26, 181-7. 
  • Cryptopleurine: an alkaloid of Cryptocarya pleurosperma. Gellert E. & Riggs N.V. Aust J Chem. 1954, 7, 113.
  • Cryptopleurine - an inhibitor of translocation. Butcher K. & Lawrence L. Biochem. 1976, 15, 4755.
  • Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. Wang Y. et al. Bioorg Med Chem. 2018, 26, 630.

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