Conglobatin B

Conglobatin B

$168.00 - 0.10 mg

$588.00 - 0.50 mg

All prices in Australian dollars

CAS #
NA
Molecular Formula
C27H36N2O6
Molecular Weight
484.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Conglobatin B was isolated from a previously unreported Streptomyces strain, phylogenetically distinct from the reported conglobatin A producer, Streptomyces conglobatus. Conglobatins B and C diverge from conglobatin through differing patterns of methylation on the macrodiolide skeleton, suggesting a deviation from the published biosynthetic pathway, which proposed three successive methylmalonyl-​CoA extender unit additions to the conglobatin monomer.  Conglobatins B and C exhibited more potent cytotoxic activity selectively against the NS-​1 myeloma cell line compared with conglobatin.

References

  • Conglobatins B-​E: cytotoxic analogues of the C2-​symmetric macrodiolide conglobatin. Lacey H.J. et al. J Antibiot 2020, 73, 756.

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