Concanamycin B

Concanamycin B

$315.00 - 0.25 mg

$1,105.00 - 1 mg

All prices in Australian dollars

Code
BIA-C1366
Synonyms
S 45B
CAS #
81552-33-2
Molecular Formula
C45H73NO14
Molecular Weight
852.06
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. Like other concanamycins and bafilomycins, concanamycin B inhibits vacuolar H(+)-ATPase. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro.

References

  • Structures of concanamycins B and C. Kinashi H. et al., J. Antibiot. 1982, 35, 1618.
  • Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro. Woo J.T. et al., Biol. Pharm. Bull. 1996, 19, 297.
  • Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. Ito K. et al., J. Antibiot. 1995, 48, 488.

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