Concanamycin B
Concanamycin B
$315.00 - 0.25 mg
$1,105.00 - 1 mg
All prices in Australian dollars
- Code
- BIA-C1366
- Synonyms
- S 45B
- CAS #
- 81552-33-2
- Molecular Formula
- C45H73NO14
- Molecular Weight
- 852.06
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Download Data Sheets
Application Notes
Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. Like other concanamycins and bafilomycins, concanamycin B inhibits vacuolar H(+)-ATPase. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro.
References
- Structures of concanamycins B and C. Kinashi H. et al., J. Antibiot. 1982, 35, 1618.
- Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro. Woo J.T. et al., Biol. Pharm. Bull. 1996, 19, 297.
- Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. Ito K. et al., J. Antibiot. 1995, 48, 488.
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