$270.00 - 0.25 mg
$945.00 - 1 mg
All prices in Australian dollars
- Folimycin, TAN 1323B
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Download Data Sheets
Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.
- The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells. Robinson D.G. et al., Protoplasma 2004, 224, 255.
- Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Kataoka T. et al., J. Immunol. 1996, 156, 3678.
- Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death. Nishihara T. et al., Biochem. Biophys. Res. Commun. 1995, 212, 255.