Collinin is a terpenylated coumarin isolated from Flindersia maculosa and other species by Ritchie and colleagues at Sydney University, Australia in 1954. Collinin possesses broad spectrum activity as an inhibitor of inflammation, collagenase and the differentiation of human preosteoclastic cells. Collinin induces apoptosis in human Jurkat T cells and is active against resistant strains of Mycobacterium tuberculosis.
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- Chemistry and pharmacology of collinin, active principle of Zanthoxylum spp. Epifano F. et al., Mini Rev. Med. Chem. 2008, 8, 1203.
- Collinin reduces Porphyromonas gingivalis growth and collagenase activity and inhibits the lipopolysaccharide-induced macrophage inflammatory response and osteoclast differentiation and function. Santos J. et al., J. Periodontol. 2013, 84, 704.
- Induction of apoptosis by collinin from Zanthoxylum schinifolium is mediated via mitochondrial pathway in human Jurkat T cells. Kim J-S. et al., Process Biochem. 2013, 48, 945.