$290.00 - 0.50 mg
$1,015.00 - 2.50 mg
All prices in Australian dollars
- Chrysomycin V, Virenomycin V, Albacarcin V,
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
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Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin A, with a vinyl group in the 8-position, is the most potent analogue of the complex, and is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. Chrysomycin A has a potent antibacterial, antifungal, antiviral and antitumor profile. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated cross-linkers of DNA to histones.
- Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of human topoisomerase II. Lorico A. et al., Eur. J. Cancer. 1993, 29A, 1985.
- Chrysomycin derivative compounds and use as antitumor agents. US Patent 6,030,951, 2000.
- Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Matsumoto A. et al., Cancer Res. 2000, 60, 3921.