Chrodrimanin B
Application Notes
Chrodrimanin B is a meroterpenoid isolated from Penicillium sp. with insecticidal properties. Chrodrimanin B attenuates the effect of GABA. Chrodrimanin B blocks the GABA-induced current in insect models, when delivered at 1 μM for 1 min prior to co-application with transmitter GABA.
References
- Novel chrodrimanin compounds and their manufacture with Penicillium. Matuso N. et al. Jpn. Kokai Tokkyo Koho (1990), JP 02221277 A 19900904.
- Elucidation and heterologous reconstitution of chrodrimanin B biosynthesis. Bai T. et al. Org Lett 2018, 20, 7504.
- Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels. Xu Y. et al. PloS One 2015, 10, e0122629.